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Office Hours:
Fall 2008:
Thursdays 12:30-2:30pm, and Fridays 10:30AM–12:15 PM, and by appointment
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Jeremy Ward
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Assistant Professor of Biology
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McCardell Bicentennial Hall 353
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Phone: 802.443.3499
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Email: jward@middlebury.edu
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Degrees, Specializations & Interests:
Degrees:
Postdoctoral Fellowship, The Jackson Laboratory, 2000-2003 (Mouse Meiotic Genetics)
Ph.D. Cornell University Medical College, 2000 (Cancer Biology)
B.A. Cornell University 1994 (Cell Biology/Genetics)
Specialization: Mammalian Genetics
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Current Research:
We are interested in the biology of meiosis, chromosome dynamics and DNA damage repair. We use molecular genetics and functional genomics techniques to physically map genes associated with gametogenesis, to identify and clone candidate genes, and to characterize the function of their protein products.
Publications (Middlebury undergraduate authors in bold type):
Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB et al. (2007) Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over. PLoS Genet 3(8): e139 doi:10.1371/journal.pgen.0030139
Kim S, Namekawa SH, Niswander LM, Ward JO, Lee JT, et al. (2007) A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet 3(4): e62. doi:10.1371/journal.pgen.0030062
Ward JO, Reinholdt LG, Hartford SA, Wilson LA, Munroe RJ, Schimenti KJ, Libby BL, O'Brien M, Pendola JK, Eppig J and Schimenti JC. (2003). Toward the genetics of mammalian reproduction: Induction and mapping of gametogenesis mutants in mice. Biol Reprod. 69:1615–1625
Ward JO, McConnell M, Licht J, Freedman LP. (2001). The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3 receptor. Blood. 98:3290-3300.
Rachez C, Suldan Z, Ward JO, Chang PB, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP. (1998). A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell free system. Genes Dev. 12:1787-1800.
Klemperer N, Ward JO, Evans E, Traktman P. (1997). The vaccinia virus I1 protein is essential for the assembly of mature virions. J Virol 71:9285-9294.
Grants:
Pending:
NSF CAREER:Toward the Genetics of Meiosis: Integration of Meiotic Molecular Biology and Public School Science Outreach. Proposed 9/09-8/14
Funded:
NIH R15, AREA. Identification and Characterization of the Mammalian Mutation Mei4. 9/06-8/09
VGN. Identification and Characterization of the Mammalian Mutation Mei4. 6/06-5/07
VGN. Identification of the Mammalian Meiotic Mutation Mei4. 9/05-5/06
NSF, MRI/RUI. Acquisition of DNA sequencing and Genotyping Instrumentation for Research and Undergraduate Training at Middlebury College. 8/03-6/05