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Titles from Previous Years

Student	Year	Title	Thesis Advisor
Adam Beard	2006	Mechanism and Kinetics of the Platinum(II) Catalyzed Oxidation of Deoxyguanosine 5'-Monophosphate by Platinum(IV) Complexes	Choi
Jonathan Berliner	2006	Variable Temperature Decarboxylation of Non-Steroidal Anti-Inflammatory Drugs	Byers
Meghan Beucher	2006	TATA-Binding Protein: Structure-Function Studies on TBP Self-Assembly	Daugherty/ Sontum
Cole Dovey	2006	Characterization of Oms28, a secreted porin of Borrelia burgdorferi	Cluss
Jay Fitzgerald	2006	Probing the Mode of Enantioselection of Chiral PHOX Ligands Through a Comparison of Electronically Modified Isomers	Bunt
Ryan Gamble	2006	The Maillard Reaction: Formation of Advanced Glycation End-Products from Ribose-5-Phosphate and Proteins	Sandwick
Brooke Gardner	2006	Role of a-enolase in Pathogenesis of Lyme Disease	Cluss
Sumaya Huque	2006	Synthesis of Sterically-Biased Complexing Agents via CBIT-Stabilized Radical Intermediates	Byers
Jakub Kostal	2006	Molecular Dynamic Studies of the Electrostatic Effects on the Vibration of Heme Bound Ligands in Myoglobin	Sontum
Jonathan Mosser	2006	Cloning, Expression, and Partial Purification of Glutamine-PRPP Amidotransferase from Escherichia Coli and Preliminary Analysis of Phosphoribosylamine, its Unstable Metabolic Product	Sandwick
William Motley	2006	Cloning and Characterization of the Mutation mei4: A Splice Donor Site Mutation in the Mouse Ortholog of the Human Enhancer of Invasion 10 (mHEI10) Leads to Late Prophase Arrest in Meiosis I	Ward
Julia West	2006	An Analysis of the Glycinamide Ribonucleatide Synthetase-Maltose Binding Protein Fusion Protein and its Substrate: Cloning, Proteolysis, Enzymatic Activity and Quantification of Phoshporibosamine	Sandwick
Elizabeth Breuer	2005	Ribose-5-Phosphate and the Maillard Reaction: Formation of Advanced Glycation End Products From Amino Acids and Proteins	Sandwick
Charlotte Carlson	2005	Evaluation of Microbial Methane Oxidation in Compost for use in Landfill Cover Soils	Larrabee
Peter Goff	2005	Radical-Catalyzed 3 Atom + 2 Atom Addition/Cyclization Reactions with Ethynylcyclopropane Reagent	Byers
Andrew Fanous	2005	Purification and Characterization of a New Splice Variant of Versican: A Porcine Spinal Cord Proteoglycan	Sandwick
Nick Janson	2005	Radical Additions Involving Metal-Arene Complexes	Byers
Naomi Kim	2005	Enantiocontrol by Phosphinooxazoline Ligands in Pd-Catalyzed Allylic Substitution Reactions	Bunt
Christine Lambert	2005	An Analysis of Methods Used in the Purification of Two Purine Synthesis Enzymes: Glutamine-PRPP Amidotransferase and GAR Synthetase	Sandwick
Amrita Sarkar	2005	Approaches to Protein Folding: Determination of the Structures of Selected Proteins of Borrelia burgdorferi Through a Combination of Theoretical Methods	Sontum
Abdel Sumrein	2005	Synthesis of Isomeric PHOX Ligands for Probing the Mechanism of Enantiocontrol in Pd-Catalyzed Allylic Substitution Reactions	Bunt
Ben Zegarelli	2005	ATRA Reactions with Derivatives of Cyclobutadieneiron Tricarbonyl and Formation of the CBIT Radical	Byers
Paul Armstrong	2004	"The Mechanism of Enantioselection in Pd-Catalyzed Allylic Substitution Reactions"
Rick Cooley	2004	"Mechanistic Studies of the Oxidation of Guanine Isomers by a Pt(IV) Complex"
Reed Gahagan	2004	"Homology Models and Molecular Analysis of Putative Carboxy-Peptidases in Borrelia burgdorferi"
Steve Gangemi	2004	"Radical Substitution: A Radical Approach to Synthetic Arene Chemistry"
Sarah Goodwin	2004	"Base Pair Flipping: The Kinetics and Dynamics of a Modified G:U Mismatch in DNA"
Matt Johanson	2004	"The Contribution of Ribose-5-Phosphate to the Maillard Reaction and Formation of Advanced Glycation End Products"
Kevin Kless	2004	"Investigation into the Extracellular Release of the Oms28 Porin by Borrelia burgdorferi"
Chin Hin Leung	2004	"A Kinetic Study on the Reduction of a Platinum(IV) Complex by Guanine-containing Deoxyribonucleotides"
Craig Szela	2004	"Identification of Exoproteins Released by Borrelia burgdorferi,the Causative Agent of Lyme Disease"
Kyle Viani	2004	"Identification of the Borrelia burgdorferi 3-hydroxy-3-methylglutaryl-CoA-reductase and Cloning of the HMGR Gene"
Adelina Voutchkova	2004	"Reactions of a Pt(IV) Complex with short Guanine—Containing oligonucleotides and 9-methyl xanthine"
J. Brad Alexander	2003	"Activation of Arenes for Radical Addition in Organic Synthesis"
Yong Zhang	2003	"The Radical Alkylation of Cyclobutadieneiron Tricarbonyl"
Thomas Stafford	2003	"The Novel Secretion of Two Proteins by Borrelia burgdorferi, and a Possible Association with Quorum Sensing"
Michelle Clasquin	2003	"Design and Building of a GC-MS inlet to detect Methyl Halides"
M. Douglas Dagan	2003	"GC-MSD Analysis of HCFC-141b Emissions From the Construction of New Buildings on the Middlebury College Campus in Middlebury, VT."
Bonnie Lee	2003	"Synthesis of Cyclopentane Derivatives using Vinylcyclopropane Radical Rearrangement"
Benjamin Wessler	2003	"Investigation of E. coli Methionine Aminopeptidase Active Site Chemistry"
Michael Mazzotta	2003	"Radical Catalyzed 3 + 2 Atom Addition/Cyclization Reactions"

Thesis Titles 1995 - 2002

Ryan	Constantine	2002	Palladium-Catalyzed Allylic-Alkylation Reactions: Using Using Phosphinooxazoline Ligands to Control En Enantioselection
Anne	DeWitt	2002	Synthesis of Indolizidine and Pyrrolizidine via Atom-Transfer Addition and Subsequent Cyclization
Amanda	Hakemian	2002	The Oxidation of Guanine by a Platinum IV Anti-Cancer Complex, PtIV(dach)Cl4
Susannah	King	2002	Determination of the Bioavailability of Cadmium and Lead in the Lake Champlain Water Column
Nicole	LeBoeuf	2002	Rates of Imino Proton Exchange in 5'-d(CGCGAATTUGCG)-3' Containing a G-U Mismatch: Kinetic Studies of Base Flipping Dynamics
Sarah	Percy	2002	The Production of Ozone Depleting Methyl Halides in Vermont Soils
John	Flanagan	2002	Determination of Mercury Levels in Lake Champlain's Water Column
Matthew	Stenmark	2002	Intrinsic Selectivity of DNA Oxidation Promoted by Platinum(IV) Complexes
Elizabeth	Williams	2002	Allosteric Modulation of the Human Methemoglobin-Nitric Oxide Interaction: Implications for Blood Pressure Regulation
Gregory	Woo	2002	The addition of Acetic Acid Derivatives to Aromat Heterocycles via Atom Transfer Radical Addition
Devin	Zarkowsky	2002	Devin Pursuing Di-radical Ring Annulations Through Novel Organometallic Processes
Ian	Zenlea	2002	Two Dimensional Gel Electrophoretic Analysis of a Putative Lipase Produced by Borrelia burgdorferi

Michael	Cooley	2001	Preparing DNA Repair Enzyme Studies
Jessica	Fields	2001	Pd-Catalyzed Allylic Substitution Reactions: How Electronics Affect Enantioselectivity
Rifat	Hasan	2001	Detection and Identification of Peroxynitrite-Induced Cysteine Oxidation in Microtubule Protein.
Syed	Masood	2001	Designing a scheme for the purification of a phospholipase PLA2 produced by the Lyme disease pathogen, Borrelia burgdorferi
Ali	McGaw	2001	The Oxidation State Selective Interaction of Cyt C with Tubulin
Fritzline	Montalmant	2001	Kinetics and Energetics of Base-Pair Opening in 5'CGCGAATTUGCG3' 3'GCGUTTAAGCGC5' Dodecamer containing a G.U mismatch
Rhonda	Moore	2001	Magnetic Circular Dichroism of E. coli Methionine Aminopeptidase
Brian	Northrop	2001	Synthesis of Indole Derivatives via Radical Aromatic Substitution
Lucian	Orbai	2001	Do Pt(IV) anticancer drugs oxidize DNA
Elizabeth	Padgett	2001	Reactivity of Platinum Anti-Cancer Complexes with DNA
Phillip	Anderson	2000	Using the Genome of the Lyme Disease Spirochete to Identify a Lipase
Craig	Breen	2000	Intramolecular Radical Cyclization Reactions on Aromatic Systems
Abraham	Butz	2000	Stereochemical Selectivity in Radical Aromatic Substitution via Atom Transfer Addition
Sarah	Cooley	2000	Detection of Peroxynitrite Induced Cystein Oxidation in Microtubule Proteins
Rachel	Davis	2000	Addition of Uracil Base to Deoxyribose Sugar in Study of the Mechanism of DNA Repair
Michael	Duff	2000	A Novel Synthesis of Pyrrole Acetic Acid Derivatives
Emily	Humphrey	2000	Peroxynitrite Induced Aggregation of Microtubule Protein via Disulfide Linkages
Matthew	Potenza	2000	The Effect of Serum Exposure on the Borrelia burgdorferi Lipase
Derek	Prabharasuth	2000	Molecular Dynamic Simulations of the A-states of Carboxy Myoglobin
Charlene	Weigel	2000	The Investigation of the DNA Repair Enzyme, Uracil DNA Glycosylase by Addition of aMethyl Group to Deoxyribose Sugar
Sohail	Yousufi	2000	The Molecular Mechanics of Carboxymyoglobin
Sarah	Delaney	1999	Reaction of Platinum(IV) Anticancer Complexes with DNA
Brian	Garvin	1999	Partial Purification of a Phospholipase A2 from Borrelia burgdorferi
David	Grass	1999	Nutrient Uptake and Release in the Tree-dwelling Vegetation of an Old-growth Temperate Rain Forest in Southern Chile
Amy	Kinner	1999	Zebra Mussels as Biomonitors of Mercury Levels in Lake Champlain
Eric	Meissner	1999	Phospholipase A2 Use by the Lyme Disease Spirochete Borrelia burgdorferi
Shwe	Mon	1999	E. Coli Methionine Aminopeptidase: Open and Close Gate Theory
Suzanne	Muchene	1999	Synthesis of Nucleoside Analogs with Restricted Backbone Conformation
Peter	Steinberg	1999	Intramolecular Cyclization at Heterocycles Using Radical Atom Transfer
Joanna	Wolkowski	1999	Control of Stereochemistry in Radical Aromatic Substitution Via Atom-Transfer Addition
Corey	Atteridge	1998	Partial Purification and Characterization of a Phospholipase A2 from Borrelia burgdorferi
Ivan	Beraha	1998	Normal Mode Analysis of CO-Mb and Related Small Molecules
Mark	Bisanzo	1998	Platinum(IV) Anticancer Complexes: Towards a Mechanism of Action Through Cell Assays, Atomic Absorption Spectroscopy, High Performance Liquid Chromatography and Cyclic Voltammetry
Judsen	Bruzgul	1998	Establishment of a Laboratory for Analysis of Trace Mercury Levels in Fish Tissue
Gregory	Burkett	1998	Stereoselective Synthesis of a Precursor to an Arylacetic Acid
John	Campbell	1998	Homolytic Alkylation Reactions of Heteroaromatic Compounds by the Atom Transfer Method
José	Dundee	1998	Partial Purification of a Phospholipase A2 in Borrelia burgdorferi
Jonathan	Kosterlitz	1998	Formation of Carbon-Carbon Bonds on an Aromatic Structure using Intramolecular Radical Cyclization Reactions
Shruthi	Mahalingaiah	1998	Reaction of Platinum(IV) Complexes with Guanosine 5'-monophosphate (5'-GMP): 1H-NMR Spectroscopic Study
Kathryn	Masselam	1998	Detection of Nitrotyrosine in Microtubule Proteins by Immunoblot Analysis
Nathan	Neale	1998	Nucleophilic Substitution Reactions by Radical Addition to Arenetricarbonylchromium Compounds
Karen	Schaper	1998	The Determination of Mercury in Sediments of Vermont Lakes and Marshes using Cold Vapor Atomic Absorption Spectroscopy
Thun	Thamrong-Nawasawat	1998	Overexpression, Purification, and Characterization of Escherichia coli Methionine Aminopeptidase
Andrew	Duncan	1997	Enantioselective Coupling of Unsaturated Organic Fragments Mediated by Chiral Titanium Alkoxides
Catherine	Filotto	1997	Reaction Chemistry of Platinum(IV) Anti-Cancer Complexes
Jenna	Mason-Plunkett	1997	Determination of DNA Copy Number and mRNA Expression Levels of the 1,25-Dihydroxyvitamin D3 Receptor Gene in Breast Cancer Cell Lines
Mark	Moynier	1997	Stereocontrolled Diol Synthesis via Radical Cyclization
Claudia	Schnipper	1997	Identification and Initial Characterization of a Membrane-Associated Phospholipase from Borrelia burgdorferi
John	Thompson	1997	Analysis of DNA Copy Number and mRNA Expression Levels of Vitamin D3 24-Hydroxylase in Breast Cancer Cell Lines
Jason	Shellhaas	1997	Radical Rearrangement Reactions of Strained Rings
Vikram	Sundar	1997	Vibration Analysis of Heme Porphyrin
Mark	Villa	1997	The Partial Characterization of a Cytosolic Phospholipase Activity From Borrelia burgdorferi
Jennifer	Whitworth	1997	Correlating Reduction Rate With Anti-Cancer Activity of Platinum(IV) Complexes
Gabriel	Belfort	1996	Fatty Acid Incorporation and Novel Lipids of Borrelia burdorferi
Kathryn	Chatfield	1996	Ishikawa Endometrial Cell Secretions: the Search for Implantation Factors
Jason	Dimmig	1996	Developing A Consistent Force Field for Hemes
Meghan	Duff	1996	Characterization of a Biotin-Containing Protein Associated with Dome Formation in Differentiating Human Endometrial (Ishikawa) Cells
William	Gowski	1996	Characterization of Membrane and Cytosolic Phospholipase A2 From the Lyme Disease Spirochete
Keith	Hoerning	1996	A New Approach to Determining Coordination Geometry About theActive Sites of Metalloenzymes Using Magnetic Circular Dichroism and Angle-Overlap Calculations
Stephen	Kocaj	1996	Characterization of a Streptococcus mutans Adherence Mutant by SDS-PAGE
Elizabeth	Prescott	1996	Nitric Oxide Synthase and Endocytosis: Possible Roles in Early Dome Formation
Jonathan	Schoenecker	1996	Identification and Characterization of a Borrelia burgdorferi Secreted Phospholipase A2 Activity
Amy	Schwenker	1996	Developing a Method for Determining the Reduction Rates of PtIV Anti-Cancer Compounds
Kathleen	Spaulding	1996	The Significance of Glutathione in Cell Media on the Cytotoxicity of PtIV Anti-Cancer Drugs
Christopher	Whitehead	1996	Addition of Electron-Rich Radicals to Electron-Deficient Alkenes via Phenyl Selenide Transfer
Stewart	Williamson	1996	Introduction of Computational Chemistry to the Organic Chemistry Curriculum: A Molecular Modeling Primer
Michael	Begley	1995	Alkaline Phosphatase Induction in Undifferentiated and Differentiated Human Endometrial Cells
Justin	Cook	1995	Co(II) Substitution in Zinc Enzymes as a Probe for Active Site Structure
Gregory	Friberg	1995	Purification Studies of a Fetal Bovine Serum Factor Which Initiates Cellular Differentiation in Endometrial Cells
Jonathan	Gilbert	1995	Investigations into the Preparation of Monocyclopentadienyl Sulfide and Thiolate Complexes of Zirconium(iv)
Lance	Klingler	1995	Zero Field Splitting of Cobalt(II) Compounds and Substituted Protein Complexes using Variable Field Variable Temperature Magnetic Circular Dichroism
James	Mack	1995	Conducting Radical Reactions in Water
Jonathan	McDonagh	1995	Characterization of Biotin Localization on the Surface of Ishikawa Cell Domes
Gregory	Okin	1995	Variable-Field Variable-temperature (VHVT) Magnetic Circular Dichroism (MCD) of Cobalt(II) Monomers and Dimers
Eileen	Shaughnessy	1995	Lactonization of Diesters at High Concentration by Radical Atom Transfer
Jameson	Thissell	1995	Radical Addition of Phenylselenomalonates to Select Aromatic Heterocycles
Nicole	Wood	1995	Reduction Kinetics of PT(IV) Anti-Cancer Compounds
Maggie	Zraly	1995	Computer Alchemy In The Carbon Monoxy Myoglobin System

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