Middlebury Formulary (By species. A data base for protocol and euthanasia information)

Science Technical Support Services

McCardell Bicentennial Hall Tech Support Laboratory Stores

Animal Programs

Euthanasia Contact Us

Institutional Review Board Contact Us

Drug Formulary

Under Construction

The following formulary was compiled from a number of sources (see "Notes" at the bottom of each page). Professional Veterinary judgment is required when using any pharmaceutical agent. Because of potential typographical errors, all dosage references should be checked prior to use and use of listed dosages is not the responsibility of this institution.

Fish
Fowl
Frog
Gerbil
Guinea Pig
Hamster

Lizard
Mouse
Mud Puppy
Rabbit
Rat
Snake

MOUSE

ANESTHETIC, ANALGESIC	Dose	Comments
ACETAMINOPHEN (TYLENOL)	1-2 MG/ML DW (14) // 300 MG/KG IP	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
ACETHYLSALICYLICATE ACID (ASPIRIN)	120-300 MG/KG PO OR 100-150 MG/KG PO q4h (14) // 25 IP/20 SC/120 PO MG/KG Q4H(2)	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
ACETYLPROMAZINE (ACEPROMAZINE) - DOSAGE	0.5-1.0 MG/KG IM (14) // 1-2 MG/KG IM	TRANQUILIZER-PHENOTHIAZINE
BUPIVACAINE (MARCAINE)	AS NEEDED	LOCAL ANESTHETIC
BUPRENORPHINE (BUPRENEX)	0.05-0.1 MG/KG IP (1)12//2 MG/KG SC (1) Q12H (2)/(4) 0.05-2.5 MG/KG SC, IP q6-12h (14) (USE 0.05)	NARCOTIC AGONIST-ANTAGONIST V
BUTORPHANOL (STADOL OR TORBUTROL)	1.5 MG/KG SC q2-4h (14) // 5.4 MG/KG SC (1)	NARCOTIC AGONIST-ANTAGONIST V
DIAZAPAM (VALIUM)	5 MG/KG IP // 3-5 MG/KG IM (14)	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - DURATION TO EFFECT	1-2 HOURS	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - TIME TO EFFECT	1-2 MIN	TRANQUILIZER - BENZODIAZEPINE IV
FENTANYL/DROPERIDOL (INNOVAR-VET)-DOSAGE	0.3-0.5 ML/KG IM (14) // 2-5 ML/KG (4)	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/ DROPERDOL - DURATION EFFECT	15-20 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL - TIME TO EFFECT	2 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL/DIAZEPAM-DOSE	5 MG/KG DIAZEPAM IP 1ST,/FOLLOWED BY 0.1 ML/30G IP OF 1:10 SALINE DILUTION INNOVAR (1)	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER, BUTYROPHENONE II
IBUPROFEN	7-15 MG/KG PO q4h (14)	ANTI-INFLAMMATORY, ANALGESIA
KETAMINE (KETASET, VETALAR) - DOSAGE	44 MG/KG IM (14) // 100-200 MG/KG IM (1)	DISSOCIATIVE
KETAMINE-ACEPROMAZINE	100/2.5 MG/KG IM (1)/ (2)	DISSOCIATIVE/TRANQUILIZER
KETAMINE-DIAZEPAM (VALIUM)	200 IM/5 IP MG/KG (1)/ (2)	DISSOCIATIVE/TRANQUILIZER
KETAMINE-XYLAZINE (ROMPUN)	50/5 MG/KG IP (14) // 200 IM/10 IP MG/KG (1)/ (2)	DISSOCIATIVE/ANALGESIC
MEPERIDINE (DEMEROL)	20 MG/KG IM SC (14) (1) Q2-3H	NARCOTIC II, ANALGESIC
METHOHEXITAL (BREVITAL/BREVANE)	6 MG/KG IV (2)	ULTRA SHORT BARBITURATE IV
MORPHINE	2-5 MG./KG SC q2-5h (14) // 10 MG/KG IM SC (1) Q2-4H (2)	NARCOTIC II, ANALGESIC
NALBUPHINE (NUBAIN)	4-8 MG/KG IM q3h (14)	NARCOTIC AGONIST-ANTAGONISTS ANALGESIC
OXYMORPHONE (NUMORPHAN) DOSAGE	0.2-0.5 MG/KG SC IM q6-12h (14)	NARCOTIC II, ANALGESIC
PENTAZOCINE (TALWIN-V)	10 MG/KG SC q2-4h (14)(2) IM IV Q3-4H (2)	NON-NARCOTIC ANALGESIC IV
PENTOBARBITAL Na (NEMBUTAL)	40 MG/KG IV IP SEDATION /50-90 MG/KG IP SURG. ANEST.(14) (1)/ (4)	BARBITURATE SHORT II, SEDATION, ANESTHETIC (NOT RECOMMENDED -MARGINAL ANALGESIA (14))
PHENYLBUTAZONE (BUTAZOLDIN)	150 MG/KG IP (7)	NONSTEROIDAL ANTI-INFLAMMATORY
PROCAINE (NOVOCAIN)	NEVER	ANESTHETIC LOCAL
PROPOFOL (RAPINOVET)	12-26 MG/KG IV (14)	ANESTHETIC
THIAMYLAL (SURITAL)	20-50 MG/KG IV IP//25-50 IV (4)	BARBITURATE ULTRA SHORT III
THIOPENTAL (PENTOTHAL)	30-40 MG/KG IV (2) ONLY (1) //25-50 IV (4)	BARBITURATE ULTRA SHORT III
TILETAMINE/ ZOLAZEPAM (TELAZOL) 50MG BASE/ML	100-160 MG/KG IP IM (1)	DISSOCIATE/TRANQUILIZER III
TRIBROMOETHANOL (AVERTIN) (0.25%)	125 MG/KG IP (1)/0.25% (2)	ANESTHETIC
XYLAZINE (ROMPUN)- DOSAGE	4-8 MG/KG IM	ALPHA-2-ADRENERGIC AGONIST SEDATIVE, ANALGESIC, MUSCLE RELAXANT
YOHIMBINE. (YOBINE)	0.5-1.0 MG/KG IV (14)	XYLAZINE REVERSAL
ANESTHETIC GAS	Dose	Comments
HALOTHANE - MAC	TO EFFECT	INHALANT
ISOFLURANE - MAC	TO EFFECT	INHALANT
METHOXYFLURANE - MAC	TO EFFECT	INHALANT
NITROUS OXIDE-MAC	TO EFFECT	INHALANT
ANTI-INFLAMMATORY	Dose	Comments
DEXAMETHASONE (AZIUM)	0.06 MG SC IM IV IP	STEROID
PREDNISONE (METICORTIN)	0.05-0.22 MG SC IM	STEROID
ANTIBIOTIC	Dose	Comments
AMIKACIN	2-5 MG/KG SC. IM q8-12h(14)	ANTIBIOTIC
AMOXICILLIN	100 MG/KG SC IM Q12H(2)	ANTIBIOTIC
AMPICILLIN (POLYFLEX)	20-100 MG/KG PO, SC, IM q12h (14) // 50-150 MG/KG SC Q12H(2) // OR 30 MG/KG IM Q24H (4.5 MG/30 MG)(3)	BETA LACTAM ANTIBIOTIC
BACITRACIN	TOPICAL	ANTIBIOTIC
CARBENICILLIN	100 MG/KG PO q12h (14)
CEPHALORIDINE (LORIDINE)	10-25 MG/KG SC, IM q24h (14)	BETA LACTAM ANTIBIOTIC
CHLORAMPHENICOL PALMITATE (CHLOROMYCETIN)	DW 0.5 MG/ML(3)(14)	BACTERIAL STATIC BROAD SPEC.
CHLORAMPHENICOL SUCCINATE (CHLOROMYCETIN)	50-200 MG/KG PO q8h OR 30-50 MG/KG SC, IM q24h (14) // 50 MG/KG IM Q12H(2) // OR Q24H (1.5 MG/30 GM)(3)	BACTERIAL STATIC BROAD SPEC.
DIHYDROSTREPTOMYCIN	NEVER	BACTERIAL
DOXYCYCLINE	2.5MG/KG PO q12h (14)	PNEUMONIA, NOT IN YOUNG OR PREGNANT
ENROFLOXACIN	25-85 MG/KG q24h X 14 DAYS OR 0.05-0.20 MG/ML DW X 14 DAYS(14)	PASTEURELLOSIS
ERYTHROMYCIN	20 MG/KG PO (14)	BACTERIAL
GENTAMICIN (GENTOCIN)	5 MG/KG SC, IM q24h (14) // 5 MG/KG SC IM SID (0.15 MG/30GM) (3)14D	AMINOGLYCOSIDES
GRISEOFULVIN (FULVICIN U/F)	25-50 MG/KG PO q12h X 14-60 DAYS (14) // 75 MG/KG PO SID 14D// OR 60 MG/KG PO IN FOOD(3)	ANTIFUNGAL
KETOCONAZOLE	10-40 MG/KG PO q24h X 14 DAYS	SYSTEMIC MYCOSES, CANDIDIASIS
NEOMYCIN (BIOSOL)	50 MG/KG SC q24h (14) // 2.6 MG/ML DW (14)	DIARRHEA
OXYTETRACYCLINE (LIQUAMYCIN)	0.4 MG/ML DW(3)(14) // 100 MG/KG SC Q12H(2)// 10-20 MG/KG PO q8h (14)	BACTERIAL STATIC BROAD SPEC.
PENICILLIN PROCAINE (AZIMYCIN)	NEVER	BACTERIAL
STREPTOMYCIN (BIOTEC)	NEVER	BACTERIAL
SULFADIMETHAXINE	10-15 MG/KG PO q12h (14)
SULFAMERAZINE	1 MG/ML DW (14) // 1 MG/4G FEED (14)	BACT. COCCIDIA, CIT,B
SULFAMETHAZINE	1 MG/ML DW (14)
SULFAQUINOXALINE (SULQUIN)	1MG/ML DW (14) // 0.025% 30days	EIMERIA, KLOS. PAST.
TETRACYCLINES	100 MG/KG SC SID (3 MG/30 GM)(3) // DW 3 MG/ML(3)	BACTERIAL STATIC BROAD SPEC//FROG RED LEG
TRIMETHOPRIM (40MG/ML)/SULPHADOXINE (200MG/ML) (TRIBRISSEN)	30 MG/KG PO, SC, IM a12h (14) // 0.5 ML/KG SC Q12H(2)	TRIMETHOPRIM / SULPHONAMIDE
TYLOSIN	0.5 MG/ML DW (14) // 10 MG/KG PO, SC, IM q24h (14) // 2-5 MG/ML DW10 MG/KG SC Q12H(2) // OR (0.3 MG/KG GM) IM(3)	MACROLIDES
ANTICHOLINERGIC	Dose	Comments
ATROPINE - DOSAGE	0.04 MG/KG SC IM(2)/(3)(14)	ANTICHOLINERGIC
ATROPINE - DURATION EFFECT	25 MIN	ANTICHOLINERGIC
ATROPINE - TIME TO EFFECT	10MIN	ANTICHOLINERGIC
ANTIPARASITIC	Dose	Comments
DICHLORVOS (TASK)	250-500 MG/KG FOOD 1D	ECTOPARASITIC-SYPH, HETER
DICHLORVOS (VOPONA STRIPS)	STRIP 48H/WK//OR1 OVER CAGE 24 H/W(3) // Suspend 15 cm above cage x 24 hr, then 2 x /wk x 3 wk (14)	ECTOPARASITIC
DIMETRIDAZOLE	1 MG/ML DW (14)	GASTROINTESTINAL PROTOZOA
DITHIAZANINE IODINE	0.1 MG/KG FOOD 7D	SYPH. HETER. STRONG.TR
FENBENDAZOLE	0.3% FEED X 14 DAYS (14) // 20 (50 FOR GIARDIASIS) MG/KG PO X 5 DAYS (14)	CESTODES, PINWORMS, GIARDIASIS
FIPRONIL (FRONTLINE)	7.5 MG/KG TOP q30-60d (14)	FLEA ADULTCIDE
IVERMECTIN (IVOMEC)	0.2 MG/KG PO, SC q7d X 3 WK (14) // 8 MG/L DW X 4 D/WK X 5 WK (14) // 200 MCG/KG PO SC(3)	MITE, PINWORMS
MEBENDAZOLE (TELMIN)	10 MG/KG PO 5D(3)	NEMATODIASIS COSMOCE
METRONIDAZOLE (FLAGYL)	15 MG/KG IP 1X	GIARDIA
NICLOSAMIDE (YOMESAN)	100 MG/KG PO(3)	CESTODES-HYMENOLEPSIS
PIPERAZINE CITRATE	2-5 MG/ML DW X 7 DAYS, OFF 7 DAY, REPEAT (14) // 100 MG/KG PO(3) // 16GM/GAL WATER + 200 ML KARO SYRUP SIDX3, REPEAT IN 2 WKS (8)	ANTI-NEMATODES-SYPHACIA & HET & PINWORMS
PRAZIQUANTEL	6-10 MG/KG PO (14) // 30 MG/KG PO q14d X 3 TX (14)	CESTODES
PYRVINIUM PAMOATE	1.6 MG/KG/D 30D	SYPH. HETER.ENTEROBIU
SULFADIMETHOXINE	10-15 MG/KG PO q12h (14)	COCCIDIOSIS
SULFAMERAZINE	1 MG/ML DW (14)	EIMERIA/COCCIDIOSIS
THIABENDAZOLE (TBZ; OMIZOLE)	1 MG/ML DW (14) // 100 MG/KG PO q24h X 5D(14)(3)	COCCIDIOSIS/ASCARIDIASIS
MISCELLANEOUS	Dose	Comments
ATROPINE	20-40 MG/ANIMAL PO (14)	ANTICHOLINERGIC
DEXAMETHASONE	0.5-2.0 MG/KG PO, SC, DECREASE DOSE q12h X 3-14 DAYS (14)	ANTI-INFLAMMATORY
DOXAPRAM	5-10 MG/KG IP, IV (14)	RESPIRATORY STIMULANT
FUROSEMIDE	5-10 MG/KG SC, IM q12h (14)	DIURETIC/PULMONARY CONGESTION/ASCITES
LACTATED RINGER'S SOLUTION	50-100 ML/KG SC, IV, IO q12h (14)	MAINTENANCE FLUID
LOPERAMIDE (IMODIUM A-D)	0.1 MG/KG PO q8h X 3 DAYS THEN q24h X 2 DAYS (GIVEN IN 1.0 ML WATER)(14)	DIARRHEA
OXYTOCIN	0.2-3 UNITS/KG SC IM IV (14)(9)	DELAYED PARTURITION, UTERINE/MILK HORM.
PREDNISONE	0.5-2.2 MG/KG SC IM (14)	ANTI-INFLAMMATORY
VITAMIN B COMPLEX	0.02-0.20 ML/KG SC IM (14)
VITAMIN D	200-400 IU/KG SC IM (14)
VITAMIN E/SELENIUM	0.1ML/100-250 G SC (14)
VITAMIN K1	1-10 MG/KG IM q214h X 4-6 DAYS (14)	WARFARIN POISONING
EUTHANASIA	Dose	Comments
Sodium pentobarbital	150 mg/kg IP	Controlled substance
Halothane	To effect	High Concentration, Rapid flow, High flow rates may initially frighten the animal, If a chamber is used Animal should not come into contact with liquid, Animals should not be overcrowded, Animals should be compatible
Isoflurane	To effect	High Concentration, Rapid flow, High flow rates may initially frighten the animal, If a chamber is used Animal should not come into contact with liquid, Animals should not be overcrowded, Animals should be compatible
CO2	To effect	No breathing, no heart beat/pulse, no response to toe/ear pinch for at least 2 minutes, Must use a gas cylinder
CO	To effect	No breathing, no heart beat/pulse, no response to toe/ear pinch for at least 2 minutes, Very hazardous, Must use a gas cylinder
Potassium chloride	1-2 mmol/kg IV or Intracardiac	Requires general anesthesia
Cervical dislocation	Conditionally acceptable	Requires another method
Decapitation	Conditionally acceptable	Requires another method
Chloral hydrate	Unacceptable
Notes		Abbreviations
(1) = Anesthesia and Analgesia in Laboratory Animals: American College of Laboratory Animal Medicine: 1990 (2) = Laboratory Animal Anesthesia: Flecknell: 1989 (3) = Drug Dosages for Small Mammals: McKellar: 1989 (4) = Recognition and Alleviation of Pain and Distress in Laboratory Animals: NRC: 1992 (5) = Current Veterinary Therapy 2 Food Animal Practice (6) = University of Calif., San Fran., Morrish (7) = Basic Care of Experimental Animals (8) = Therapeutic Guide and Anesthesia, O'Harndley (9) = The Biology and Medicine of Rabbits and Rodents (10) = ???????? Continuing Education Vol. 5, No. 4, April 1992 (11) = USUHS Formulary (12) = LAB ANIMAL OCT 91 PAGE 34 (13) = Anesthesia and Analgesia Doses, SCHAEFFER, KNOXVILLE, TN (14) = Exotic Animal Formulary, Carpenter, Saunders:2001	EOD = Every Other Day SID = Once a day BID = Twice a day (generally every 12 hours) TID = Three times a day (every 8 hours) QID = Four times a day (every 6 hours) Q?H = Every ? hours IM = Intramuscular injection IP = Intraperitoneal injection SC or SQ = Subcutaneous injection IV = Intravenous injection PO = Per Os (By Mouth) (Orally) DW = Drinking water 3DX4 = 3 days of treatment, repeated 4 times

RAT

ANESTHETIC, ANALGESIC	Dose	Comments
ACETAMINOPHEN (TYLENOL)	1- MG/ML DW (14) // 110-300 MG/KG PO(4)	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
ACETHYLSALICYLICATE ACID (ASPIRIN)	100 MG/KG PO Q4H(2)(4) // 20 SC(1)	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
ACETYLPROMAZINE (ACEPROMAZINE) - DOSAGE	0.5-1.0 MG/KG IM (14) // 1-2 MG/KG IM	TRANQUILIZER-PHENOTHIAZINE
ALPHA CHOLORALOSE (NOT SURVIVAL) 5%	45-65 MG/KG IP(1)	HYPNOTIC
BUPIVACAINE (MARCAINE)	AS NEEDED	LOCAL ANESTHETIC
BUPRENORPHINE (BUPRENEX)	0.02-0.50 MG/KG SC, IP, IV q6-12h (14) // 0.01-0.1 (.05) MG/KG IP(1) 12 //0.1-0.5 MG/KG SC(1) /IV Q8-12 (2)/(4) (USE 0.05)	NARCOTIC AGONIST-ANTAGONIST V, ANALGESIC
BUTORPHANOL (STADOL OR TORBUTROL)	1-5 MG/KG SC q2-4h (14) // 23.3 MG/KG SC(1)	NARCOTIC AGONIST-ANTAGONIST V, ANALGESIC
CHLORAL HYDRATE 5%	300-450 MG/KG IP(1) NOTE: A DYNAMIC ILEUS	HYPNOTIC
DIAZAPAM (VALIUM) DOSAGE	3-5 MG/KG IM (14) // 2.5 MG/KG IP	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - DURATION OF EFFECT	1-2 HOURS	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - TIME TO EFFECT	2-3 MIN	TRANQUILIZER - BENZODIAZEPINE IV
FENTANYL/DROPERIDOL (INNOVAR-VET)-DOSAGE	0.3-0.5 ML/KG IM (14) // 0.02-0.06 ML/100GM IP / 0.3 ML/KG IM(1)	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERDOL - DURATION EFFECT	15-30 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL - TIME TO EFFECT	8/3 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FLUNIXIN MEGLUMINE	2.5 MG/KG SC q12-24h (14)	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
IBUPROFEN	10-30 MG/KG PO q4h	ANALGESIC, ANTI-INFLAMMATORY
INACTIN	80 MG/KG IP(1)/(2)	ULTRA SHORT BARBITURATE
KETAMINE (KETASET, VETALAR)	22 MG/KG IM (25-40 MG/KG HEAVY SEDATION) (14) // 60-100 MG/KG IM(1)	DISSOCIATIVE, CONTROLLED SUBSTANCE
KETAMINE-ACEPROMAZINE	40-80 IP/2.5 IP IM MG/KG (1)//75/2.5 IM(2)	DISSOCIATIVE/TRANQUILIZER
KETAMINE-DIAZEPAM (VALIUM)	40-80/5-10 MG/KG IP(1)	DISSOCIATIVE/TRANQUILIZER
KETAMINE-XYLAZINE (ROMPUN)	75-95/5 MG/KG IM IP (14) // 40-80/5-10 MG/KG IP IM(1) NOTE: STUDY SHOWED SEVERE NECROSIS IM(1)	DISSOCIATIVE/ANALGESIC
MEPERIDINE (DEMEROL)	20 MG/KG IM SC(1)(14) Q2-3H	NARCOTIC II
METHOHEXITAL (BREVITAL/BREVANE)	7-10 MG/KG IV (2) // 95 MG/KG IP (6)	ULTRA SHORT BARBITURATE IV
MORPHINE	2-5 MG/KG SC q2-4h (14) // 10 MG/KG IM SC (1)Q2-4H(2)	NARCOTIC II
NALBUPHINE (NUBAIN)	4-8 MG/KG IM q3h (14)	NARCOTIC AGONIST-ANTAGONIST ANALGESIC
NALOXONE (NARCAN)	0.01-0.1. MG/KG SC IP (14)	NARCOTIC REVERSAL
OXYMORPHONE (NUMORPHAN) DOSAGE	0.2-0.5 MG/KG SC IM q6-12h (14) // 0.25-0.5 MG/KG IM	NARCOTIC II
PENTAZOCINE (TALWIN-V)	10 MG/KG SC q2-4h (14) // 10 MG/KG SC(2) IM IV Q4H(2)	NON-NARCOTIC ANALGESIC IV
PENTOBARBITAL Na (NEMBUTAL)	30-45 MG/KG IP (14) // 40 MG/KG IV IP SEDATION / 60-100 MG/KG IM SURG. ANEST.(1)//25-40 IP(4)	BARBITURATE SHORT II, NOT RECOMMENDED, MARGINAL ANALGESIA (14)
PHENYLBUTAZONE (BUTAZOLDIN)	7.5-15 SC /30-100 PO MG/KG (4)	NONSTEROIDAL ANTI-INFLAMMATORY
PROCAINE (NOVOCAIN)	NEVER	ANESTHETIC LOCAL
PROPOFOL (RAPINOVET)	7.5-10.0 MG/KG IV (14)	ANESTHESIA
THIAMYLAL (SURITAL)	20-50 MG/KG IV IP	BARBITURATE ULTRA SHORT III
THIOPENTAL (PENTOTHAL)	30 MG/KG IV(3)/20-25 IV(4)	BARBITURATE ULTRA SHORT III
TILETAMINE/ZOLAZEPAM (TELAZOL) 50MG BASE/ML	20-40 MG/KG IP 20 IM(1)(14)	DISSOCIATE/TRANQUILIZER III
TRIBROMOETHANOL (AVERTIN) (0.25%)	300 MG/KG IP(1)/(2)	ANESTHETIC, PERITONEAL ADHESIONS IS NOT FRESHLY PREPARED. 2ND ADMINISTRATION OFTEN ASSOCIATED WITH DEATH
XYLAZINE (ROMPUN)- DOSAGE	4-8 MG/KG IM	ALPHA-2-ADRENERGIC AGONIST SEDATIVE, ANALGESIC, MUSCLE RELAXANT
YOHIMBINE. (YOBINE)	1-2MG/KG	XYLAZINE REVERSAL
ANESTHETIC GAS	Dose	Comments
HALOTHANE	TO EFFECT	INHALANT
ISOFLURANE	TO EFFECT	INHALANT
METHOXYFLURANE	TO EFFECT	INHALANT
NITROUS OXIDE	TO EFFECT	INHALANT
ANTI-INFLAMMATORY	Dose	Comments Back to Top
DEXAMETHASONE (AZIUM)	0.5-2.0 MG/KG PO SC THEN DECREASING DOSE q12h X 3-14 DAYS (14) // 0.06 MG SC IM IV IP	STEROID
PREDNISONE (METICORTIN)	0.5-0.22 MG SC IM(14)	STEROID
ANTIBIOTIC	Dose	Comments Back to Top
AMIKACIN	2-5 MG/KG SC IM q8-12h (14)	ANTIBIOTIC
AMOXICILLIN	150 MG/KG SC IM Q12H(2)	ANTIBIOTIC
AMPICILLIN (POLYFLEX)	20-100 MG/KG PO SC IM q12h (14) // 2-10 MG/100GM PO BID// OR 50-150 SC Q12H(2) // OR 150 MG/KG Q12H SC(3)	BETA LACTAM ANTIBIOTIC
BACITRACIN	TOPICAL	ANTIBIOTIC
CARBENICILLIN	100 MG/KG PO q12h (14)	ANTIBIOTIC
CEPHALORIDINE (LORIDINE)	10-25 MG/KG SC IM q24h (14) // 30 IM Q12H(2) // OR 30	BETA LACTAM ANTIBIOTIC
CHLORAMPHENICOL PALMITATE (CHLOROMYCETIN)	50-200 MG/KG PO q8h (14) // 50 MG/KG PO BID(3)// OR DW 0.83 MG/ML(3)	BACTERIAL STATIC BROAD SPEC.
CHLORAMPHENICOL SUCCINATE (CHLOROMYCETIN)	30-50 MG/KG SC IM q12h (14) // 50 MG/KG IM SID 5D(3) // OR Q12H(2)	BACTERIAL STATIC BROAD SPEC.
CIPROFLOXACIN	7-20 MG/KG PO q12h (14)	BACTERIAL
DIHYDROSTREPTOMYCIN	NEVER	BACTERIAL
DOXYCYCLINE	5 MG/KG PO q12h (14)	BACTERIAL PNEUMONIA. NOT IN YOUNG OR PREGNANT ANIMALS
ENROFLOXACIN	2.5-5.0 MG/KG PO SC IM q12h (14)	BACTERIAL
GENTAMICIN (GENTOCIN)	5 MG/KG SC IM q12h(14)(3)14D	AMINOGLYCOSIDES
GRISEOFULVIN (FULVICIN U/F)	25-50 MG/KG PO q12h X 14-60 DAYS (14) // 60 MG/KG PO IN FOOD(3)	ANTIFUNGAL
METRONIDAZOLE	10-40 MG/ANIMAL PO q8h(14)	BACTERIAL, ANAEROBES, ADD SUCROSE
NEOMYCIN SULFATE	0.5 MG/ML DW OR 50 MG/KG SC q24h (14)	AMINOGLYCOSIDES, DIARRHEA
OXYTETRACYCLINE (LIQUAMYCIN)	0.4 MG/ML DW OR 10-20 MG/KG PO q8h(14) // DW 0.4 MG/ML(3)// 100 MG/KG SC Q12H(2)	BACTERIAL STATIC BROAD SPEC.
STREPTOMYCIN (BIOTEC)	NEVER	BACTERIAL
SULFADIMETHOXINE	10-15 MG/KG PO q12h (14)	BACTERIAL
SULFAMERAZINE	1 MG/4 G FEED (14) OR 1 MG/ML DW (14)	BACTERIAL
SULFAMETHAZINE	1 MG/ML DW (14) // OR DW 0.02%(2)	BACT. COCCIDIA, CIT,B
SULFAQUINOXALINE (SULQUIN)	0.25-1.0 MG/ML DW (14) // 0.025% 30days	EIMERIA, KLOS. PAST.
TETRACYCLINES	2-5 MG/ML DW (14) OR 10-20 MG /KG PO q8-12h (14) // 100 MG/KG SC SID)(3) // DW 0.55 MG/ML(3)	BACTERIAL STATIC BROAD SPEC//FROG RED LEG
TRIMETHOPRIM (40MG/ML)/SULPHADOXINE (200MG/ML) (TRIBRISSEN)	30 MG/KG PO SC IM q12h (14) // 0.5 ML/KG SC Q12h(2)	TRIMETHOPRIM / SULPHONAMIDE
TYLOSIN	0.5 MG/KG DW OR 10 MG/KG PO SC IM q12h (14) // 10 MG/KG SC Q12H(2) // OR IM(3)	MACROLIDES
ANTICHOLINERGIC	Dose	Comments Back to Top
ATROPINE - DOSAGE	0.05 MG/KG SC IM(3)(14)	ANTICHOLINERGIC
ATROPINE - DURATION EFFECT	15 MIN	ANTICHOLINERGIC
ATROPINE - TIME TO EFFECT	10 MIN	ANTICHOLINERGIC
ANTIPARASITIC	Dose	Comments Back to Top
DICHLORVOS (VOPONA STRIPS)	STRIP 48H/WK//OR1 OVER CAGE 24 H/W(3)	ECTOPARASITIC
FENBENDAZOLE	20 MG/KG PO q24h X 5 DAYS (50 FOR GIARDIA) (14)	BACTERIAL
IVERMECTIN (IVOMEC)	0.2 MG/KG PO SC q7d X 3 WK MITES (14) OR 25 MG/ML DW 4DAYS/WK X 5 WK PINWORMS (14) // 200 MCG/KG PO SC(3)	ANTI-NEMATODES/ECTOPARASITIC, MITES
MEBENDAZOLE (TELMIN)	10 MG/KG PO 5D(3)	NEMATODIASIS COSMOCE
NICLOSAMIDE (YOMESAN)	100 MG/KG PO(3)	CESTODES-HYMENOLEPSIS
PIPERAZINE	2-5 MG/ML DW X 7 DAYS, OFF 7 DAYS, REPEAT (14) // 100 MG/KG PO(3) // 16GM/GAL WATER + 200 ML KARO SYRUP SIDX3, REPEAT IN 2 WKS (8)	ANTI-NEMATODES-SYPHACIA & HET & PINWORMS
PRAZIQUANTEL	30 MG/KG PO q14d X 3 TX (14)	CESTODES
PYRVINIUM PAMOATE	0.003% H20 30D	SYPH. HETER. ENTEROBIU
SULFAMETHAZINE ETC. (VETA-METH)	1 MG/ML DW (14)	EIMERIA
THIABENDAZOLE (TBZ; OMIZOLE)	100 MG/KG PO q24h X 5 DAYS // 100 MG/KG PO 5D(3)	ANTI-NEMATODES - OPHIDAS
MISCELLANEOUS	Dose	Comments Back to Top
DEXAMETHASONE	0.5-2.0 MG/KG PO SC DECEASE DOSE Q12H X 3-14 DAYS (14)	ANTI-INFLAMMATORY
DOXAPRAM -DOPRAM V-DOSAGE	5-10 MG/KG IV(3) OR IP (14)	ANALEPTIC, RESPIRATORY STIMULANT
FUROSEMIDE	5-10 MG/KG SC IM q12h (14)	DIURETIC
LACTATED RINGER'S SOLUTION	50-100 ML/KG SC, IV IO q24h (14)	MAINTENANCE FLUID
OXYTOCIN	0.2-3.0 IU/KG SC IM IV (14) // 0.2-3 UNITS/KG SC IM(9)	UTERINE/MILK HORM., DELAYED PARTURITION
PREDNISONE	0.5-2.2 MG/KG SC IM (14)	ANTI-INFLAMMATORY
VITAMIN B COMPLEX	0.02-0.20 MG/KG SC IM	SUPPLEMENT
VITAMIN D	200-400 IU/KG SC IM (14)	SUPPLEMENT
VITAMIN E	0.1 ML/100-250G SC	SUPPLEMENT
VITAMIN K1	1-5 MG/KG IM q24h X 4 DAYS TO 4 WEEKS	POISONING
EUTHANASIA	Dose	Comments Back to Top
Sodium pentobarbital	150 mg/kg IP	Controlled substance
Halothane	To effect	High Concentration, Rapid flow
Isoflurane	To effect	High Concentration, Rapid flow
CO2	To effect	Requires some other method to ensure death
CO	To effect	See hazards under euthanasia training
Potassium chloride	1-2 mmol/kg IV IC	Requires general anesthesia
Cervical dislocation	Conditionally acceptable, Less than 200 grams	Requires scientific justification by user and approval of IACUC, Requires special training and monitoring
Decapitation	Conditionally acceptable	Requires scientific justification by user and approval of IACUC, Requires special training and monitoring, Hazard, requires special training for hazard, Equipment has to be maintained
Chloral hydrate	Unacceptable	Not used in rats

Notes

Abbreviations Back to Top

(1) = Anesthesia and Analgesia in Laboratory Animals: American College of Laboratory Animal Medicine: 1990
(2) = Laboratory Animal Anesthesia: Flecknell: 1989
(3) = Drug Dosages for Small Mammals: McKellar: 1989
(4) = Recognition and Alleviation of Pain and Distress in Laboratory Animals: NRC: 1992
(5) = Current Veterinary Therapy 2 Food Animal Practice
(6) = University of Calif., San Fran., Morrish
(7) = Basic Care of Experimental Animals
(8) = Therapeutic Guide and Anesthesia, O'Harndley
(9) = The Biology and Medicine of Rabbits and Rodents
(10) = ???????? Continuing Education Vol. 5, No. 4, April 1992
(11) = USUHS Formulary
(12) = LAB ANIMAL OCT 91 PAGE 34
(13) = Anesthesia and Analgesia Doses, SCHAEFFER, KNOXVILLE, TN
(14) = Exotic Animal Formulary, Carpenter, Saunders:2001

EOD = Every Other Day SID = Once a day BID = Twice a day (generally every 12 hours) TID = Three times a day (every 8 hours) QID = Four times a day (every 6 hours) Q?H = Every ? hours IM = Intramuscular injection IO = Intraosseous injection IP = Intraperitoneal injection SC or SQ = Subcutaneous injection IV = Intravenous injection PO = Per Os (By Mouth) (Orally) DW = Drinking water 3DX4 = 3 days of treatment, repeated 4 times

RABBIT

ANESTHETIC, ANALGESIC	Dose	Comments
ACETAMINOPHEN (TYLENOL)	200-500 MG/KG PO OR 1-2 MG/ML DW (14)	NONSTEROIDAL ANTI-INFLAMMATORY
ACETHYLSALICYLICATE ACID (ASPIRIN)	100 MG/KG PO q4-48h (14)	NONSTEROIDAL ANTI-INFLAMMATORY
ACETYLPROMAZINE (ACEPROMAZINE) - DOSAGE	0.5-5.0 MG/KG SC IM (14)	TRANQUILIZER-PHENOTHIAZINE
BUPIVACAINE (MARCAINE)	AS NEEDED	LOCAL ANESTHETIC
BUPRENORPHINE (BUPRENEX)	0.01-0.05 MG/KG SC IP IV q6-12h (14) // 0.01 MG/KG SC*// OR.02-.05 SC IV Q8-12H(2)/(4)	NARCOTIC AGONIST-ANTAGONIST V
BUTORPHANOL (STADOL OR TORBUTROL)	0.1-0.5 MG/KG SC IM IV q2-4h (14)	NARCOTIC AGONIST-ANTAGONIST V
DIAZAPAM (VALIUM) DOSAGE	1-10 MG/KG IM (14) // 5-10 MG/KG IM	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - DURATION TO EFFECT	1-2 HOURS	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - TIME TO EFFECT	5-10/1 MIN	TRANQUILIZER - BENZODIAZEPINE IV
FENTANYL (SUBLIMAZE)	0.0074 MG/KG IV (14)	NARCOTIC II
FENTANYL/DROPERIDOL (INNOVAR-VET)-DOSAGE	0.15- 0.44 MG/KG IM (14) // 0.15-0.5 ML/KG IM OR 0.18-0.23 ML/KG (1)	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERDOL - DURATION EFFECT	20-30 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL - TIME TO EFFECT	6-10 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FLUNIXIN MEGLUMINE (BANAMINE)-DOSAGE	0.3-2.0 MG/KG PO IM IV q12-24h	NON-NARCOTIC, NON-STEROIDAL ANALGESIC. USE FOR NO MORE THAN 3 DAYS
IBUPROFEN	7.5 MG/KG PO q6-8h	NONSTEROIDAL ANTI-INFLAMMATORY, ANALGESIC
KETAMINE (KETASET, VETALAR)	15-20 MG/KG IV OR 20-50 MG/KG IM (14) // 35 MG/KG IM FOLLOWED WITH INACTIN TO EFFECT (1) // OR 50 IM (2)	DISSOCIATIVE
KETAMINE - DURATION EFFECT	60 MINUTES	DISSOCIATIVE
KETAMINE-ACEPROMAZINE	40/0.5-1.0 MG/KG IM (14) // 60/1 MG/KG IM //OR KETAMINE 35 MG/KG IM+ XYLAZINE 5 MG/KG IM+ ACEPROMAZINE 0.75 MG/KG SC (1) //OR KET 50 IM + XYL 3 IM + ACE 1 SC(1) ///OR 75/5 IM(2)	DISSOCIATIVE/TRANQUILIZER
KETAMINE-DIAZEPAM (VALIUM)	20-40/1-3 MG/KG IM (14) // 25-35/5-10 MG/KG IM(1)	DISSOCIATIVE/TRANQUILIZER, GENERALLY FOLLOWED BY ISOFLURANE
KETAMINE-XYLAZINE (ROMPUN)	10-40/3-5 MG/KG IM (14) // 35-50/5-10 MG/KG IM(1)	DISSOCIATIVE/ANALGESIC
KETAMINE-XYLAZINE-ACEPROMAZINE	35/5/0.75 MG/KG IM (14)	DISSOCIATIVE/ANALGESIC/TRANQUILIZER
MEPERIDINE (DEMEROL)	5-25 MG/KG SC IM IV OR 0.2 MG/KG DW (14) // 5-10 MG/KG SC IM IV Q2-3H	NARCOTIC II, ANALGESIC
METHOHEXITAL (BREVITAL/BREVANE)	10 MG/KG IV (2)	ULTRA SHORT BARBITURATE IV
MORPHINE	1.2-10 MG/KG q2-4h (14) // 2-5 IV/5 SC IM MG/KG Q2-3H (1)/(2)	NARCOTIC II, ANALGESIC
NALBUPHINE (NUBAIN)	1-2 MG/KG IM IV q4-5h (14)	NARCOTIC AGONIST-ANTAGONIST ANALGESIC
NALOXONE	00.1-0.1. MG/KG IM IV	NARCOTIC REVERSAL
OXYMORPHONE (NUMORPHAN)	0.05-0.20 MG/KG SC IM q8-12h (14)	NARCOTIC II, ANALGESIC
PENTAZOCINE (TALWIN-V)	5-10 MG/KG IM IV q2-4h (14) // 10-20 MG/KG SC IM Q4H (2)	NON-NARCOTIC ANALGESIC IV
PENTOBARBITAL Na (NEMBUTAL)	20-45 MG/KG IP IV (14) // 20-45 MG/KG IV OR TO EFFECT (SAFER WITH -10 MG/KG ACEP. OR 5 XYLAZ OR 25 MEPER)(1)	BARBITURATE SHORT II, MARGINAL ANALGESIC, NOT RECOMMENDED
PHENCYCLIDINE - DOSAGE	4 MG/KG IM	TRANQUILIZER
PHENCYCLIDINE - DURATION	20-60 MIN	TRANQUILIZER
PHENCYCLIDINE - TIME EFFECT	5-10 MIN	TRANQUILIZER
PHENCYCLIDINE - TIME FULL RECOVERY	2 HOURS	TRANQUILIZER
PHENYLBUTAZONE (BUTAZOLDIN)	75 MG/KG PO IV QID	NONSTEROIDAL ANTI-INFLAMMATORY
PROMAZINE (SPARINE)	1-2 MG/KG IM IV (14)	TRANQUILIZER
PROPOFOL	2-15 MG/KG IV (14)	INDUCTION FOR ANESTHESIA
THIAMYLAL (SURITAL)	15-25 MG/KG 1% IV (14) OR TO EFFECT (SAFER WITH -10 MG/KG ACEP. OR 5 XYLAZ OR 25 MEPER) (1) //20-50 IV(4)	BARBITURATE ULTRA SHORT III
THIOPENTAL (PENTOTHAL)	15-30 MG/KG IV TO EFFECT (14) // 15-25 MG/KG 1% IV OR TO EFFECT (SAFER WITH 10 MG/KG ACEP. OR 5 XYLAZ. OR 25 MEPER) (1) // 15-30 IV (4)	BARBITURATE ULTRA SHORT III
TILETAMINE/ZOLAZEPAM (TELAZOL) 50MG BASE/ML	3 MG/KG IM (14)	DISSOCIATE/TRANQUILIZER III, CAN CAUSE RENAL NECROSIS, GENERALLY NOT RECOMMENDED
XYLAZINE (ROMPUN)	1-3 MG/KG SC IM (14) // 5 MG/KG SC FOLLOWED BY INACTIN TO EFFECT (1)	ALPHA-2-ADRENERGIC AGONIST SEDATIVE, ANALGESIC, MUSCLE RELAXANT, GENERALLY NOT RECOMMENDED WITHOUT COMBINATION
XYLAZINE - TIME TO EFFECT	RAPID	ALPHA-2-ADRENERGIC AGONIST SEDATIVE, ANALGESIC, MUSCLE RELAXANT
YOHIMBINE (YOBINE)	0.2-1.0 IM IV (14) // 0.2 MG/KG IV	XYLAZINE REVERSAL
ANESTHETIC GAS	Dose	Comments
HALOTHANE	TO EFFECT	INHALANT, SAFER AFTER 1MG/KG ACEPROMAZINE(1)
ISOFLURANE	TO EFFECT	INHALANT, SAFER AFTER 1MG/KG ACEPROMAZINE(1)
METHOXYFLURANE	TO EFFECT	INHALANT, SAFER AFTER 1MG/KG ACEPROMAZINE(1)
ANTI-INFLAMMATORY	Dose	Comments
DEXAMETHASONE (AZIUM)	0.2-0.6 MG/KG SC IM IV (14) // 0.06 MG SC IM IV IP	STEROID
PREDNISONE (METICORTIN)	0.25-0.50 MG/KG PO q12h X 3 DAYS, THEN q24h X 3 DAYS, THEN q48h (14) // 0.05-0.22 MG SC IM	STEROID
ANTIBIOTIC	Dose	Comments
AMOXICILLIN		ANTIBIOTIC
AMPICILLIN (POLYFLEX)	10-25 MG/KG IM SID 7D // OR 25 MG/KG IM Q24H (TOXIC?) (3)	BETA LACTAM ANTIBIOTIC
BACITRACIN	TOPICAL	ANTIBIOTIC
CEPHALORIDINE (LORIDINE)	30 MG/KG SID IM (3)	BETA LACTAM ANTIBIOTIC
CEPHALOTHIN SODIUM	13 MG/KG IM QID 6D	PAST.
CHLORAMPHENICOL PALMITATE (CHLOROMYCETIN)	50 MG/KG PO SID (3)//DW 1.3 MG/KL (3)	BACTERIAL STATIC BROAD SPEC.
CHLORAMPHENICOL SUCCINATE (CHLOROMYCETIN)	30 MG/KG IM 5D (3)	BACTERIAL STATIC BROAD SPEC.
FURAZOLIDONE (TOPAZONE)	5 MG/100GM FEED SID	PAST.
GENTAMICIN (GENTOCIN)	5 MG/KG IM SID 5D (3)	AMINOGLYCOSIDES
GRISEOFULVIN (FULVICIN U/F)	25 MG/KG PO IN FOOD (3)	ANTIFUNGAL
OXYTETRACYCLINE (LIQUAMYCIN)	15 MG/KG SC IM (2)/ (3) // DW 0.7 MG/ML (3)	BACTERIAL STATIC BROAD SPEC.
PENICILLIN	20-30,000 IM 5-7D	ANITBIOTIC
PENICILLIN - BENZATHIN/PROCAINE(BICILLIN)(FLOCILLIN)	120,000 UI/KG EOD IM	BACTERIAL
PENICILLIN PROCAINE (AZIMYCIN)	40,000 IU/KG SID 5-7D	BACTERIAL
POTASSIUM PERMANGANATE		FUNGAL CUTANEOUS
STREPTOMYCIN (BIOTEC)	20 mg/kg 5-7DAY	BACTERIAL
SULFAMETHAZINE OR SULFAMERAZINE	DW 1 MG/KL (3)	BACT. COCCIDIA,CIT,B
SULFAQUINOXALINE (SULQUIN)	DW 1 MG/KL (3)	EIMERIA,KLOS. PAST.
TETRACYCLINES	300 MG/KG (0.4-1 GM/L)/50 MG/KG Q12H PO (3)// DW 0.7 MG/ML (3)	BACTERIAL STATIC BROAD SPEC//FROG RED LEG
TOLNAFTATE (TINACTIN)	TOPICAL	FUNGAL TOPICAL
TRIMETHOPRIM (40MG/ML)/SULPHADOXINE (200MG/ML) (TRIBRISSEN)	0.2 ML/KG SC Q12H(2) // OR 30 MG/KG SC Q24H (3)	TRIMETHOPRIM / SULPHONAMIDE
TYLOSIN	66 MG/L 21D	MACROLIDES
ANTICHOLINERGIC	Dose	Comments Back to Top
ATROPINE - DOSAGE	0.2 MG/KG IM (2)/ (3)	ANTICHOLINERGIC
ATROPINE - DURATION EFFECT	15 MIN	ANTICHOLINERGIC
ATROPINE - TIME TO EFFECT	20 MIN	ANTICHOLINERGIC
ANTIPARASITIC	Dose	Comments Back to Top
CARBARYL POWDER (DIRYL)	5 D	ECTOPARASITIC
DICHLORVOS (TASK)	500 MG/KG IN FEED/24H	ECTOPARASITIC-SYPH, HETER
DICHLORVOS (VOPONA STRIPS)	STRIP 48H/WK	ECTOPARASITIC
IVERMECTIN (IVOMEC)	200 MCG/KG PO SC (3)	ANTI-NEMATODES/ECTOPARASITIC
MEBENDAZOLE (TELMIN)	10 MG/KG PO 5D (3)	NEMATODIASIS COSMOCE
NICLOSAMIDE (YOMESAN)	100 MG/KG PO (3)	CESTODES-HYMENOLEPSIS
PIPERAZINE	100 MG/KG PO (3)// 200 MG/KG PO (9)	ANTI-NEMATODES-SYPHACIA & HET & PINWORMS
SUCCINYSULFATHIAZOLE	0.02-0.1% IN WATER	EIMERIA
SULFAMETHAZINE ETC. (VETA-METH)	.5-1% IN FEED	EIMERIA
THIABENDAZOLE (TBZ; OMIZOLE)	100 MG/KG PO 5D (3)	ANTI-NEMATODES - OPHIDAS
MISCELLANEOUS	Dose	Comments
OXYTOCIN	0+L16.2-3 UNITS/KG SC IM (9)	UTERINE/MILK HORM.
DOXAPRAM -DOPRAM V-DOSAGE	2-5 MG/KG IV (3)	ANALEPTIC
EUTHANASIA	Dose	Comments
Sodium pentobarbital	90 mg/kg IV
Halothane	To effect	High concentrations, Rapid flow, Neonates tolerate hypoxia too well to use this method, Equipment has to be maintained, Requires some other method of euthanasia to ensure death such as removal of vital organ, exsanguination, or open ch
Isoflurane	To effect	High concentrations, Rapid flow, Neonates tolerate hypoxia too well to use this method, Equipment has to be maintained, Requires some other method of euthanasia to ensure death such as removal of vital organ, exsanguination, or open ch
CO2	to effect	Must use gas cylinder, Requires some other method of euthanasia to ensure death such as removal of vital organ, exsanguination, or open chest
CO	To effect	Must use gas cylinder, Requires some other method of euthanasia to ensure death such as removal of vital organ, exsanguination, or open chest,Special hazard training required
Potassium chloride	1-2 mmol/kg	Requires general anesthesia
Cervical dislocation	Conditionally acceptable	Less than 1 kg, Requires scientific justification by user and approval of IACUC, Requires special training and monitoring
Decapitation	Conditionally acceptable	Requires special training and monitoring
Penetrating captive bolt	Conditionally acceptable
Chloral hydrate	UNACCEPTABLE

Notes

Abbreviations

EOD = Every Other Day SID = Once a day BID = Twice a day (generally every 12 hours) TID = Three times a day (every 8 hours) QID = Four times a day (every 6 hours) Q?H = Every ? hours IM = Intramuscular injection IP = Intraperitoneal injection SC or SQ = Subcutaneous injection IV = Intravenous injection PO = Per Os (By Mouth) (Orally) DW = Drinking water 3DX4 = 3 days of treatment, repeated 4 times

HAMSTER

ANESTHETIC, ANALGESIC
ACETAMINOPHEN (TYLENOL)	240 MG/KG IP *7	NONSTEROIDAL ANTI-INFLAMMATORY
ACETHYLSALICYLICATE ACID (ASPIRIN)	20 MG/KG SC *?	NONSTEROIDAL ANTI-INFLAMMATORY
ACETYLPROMAZINE (ACEPROMAZINE) - DOSAGE	1-2 MG/KG IM	TRANQUILIZER-PHENOTHIAZINE
ALPHA CHOLORALOSE (NOT SURVIVAL) 5%	8-10 MG/100GM IP OF 1	HYPNOTIC
BUPIVACAINE (MARCAINE)	AS NEEDED	LOCAL ANESTHETIC
BUPRENORPHINE (BUPRENEX)	0.5-5.0 MG/KG SC	NARCOTIC AGONIST-ANTAGONIST V
CHLORAL HYDRATE 5%	200-360 MG/KG IP	HYPNOTIC
DIAZAPAM - DURATION TO EFFECT	1-2 HOURS	TRANQUILIZER - BENZODIAZEPINE IV
DIAZAPAM - TIME TO EFFECT	2-3 MIN	TRANQUILIZER - BENZODIAZEPINE IV
DOXAPRAM -DOPRAM V-DOSAGE	5-10 MG/KG IV***	ANALEPTIC
FENTANYL/DROPERIDOL (INNOVAR-VET)-DOSAGE	0.15 ML/100GM IP*	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERDOL - DURATION EFFECT	15-20 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL - TIME TO EFFECT	2 MIN	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER II
FENTANYL/DROPERIDOL/DIAZEPAM-DOSE	1ML/KG + 5MG/KG IP*	NEUROLEPTANALGESIC, NARCOTIC/BUTYROPHENONE TRANQUILIZER,BUTYROPHENONE II
KETAMINE (KETASET, VETALAR) - DOSAGE	40-200 MG/KG IM-IP	DISSOCIATIVE
KETAMINE-ACEPROMAZINE	150/5 MG/KG IM/*	DISSOCIATIVE/TRANQUILIZER
KETAMINE-XYLAZINE (ROMPUN)	100-200 IP OR 80 IM/7-10 MG/KG IM IP//OR 200/10 IP*	DISSOCIATIVE/ANALGESIC
MEPERIDINE (DEMEROL)	20 MG/KG IM SC*Q2-3H	NARCOTIC II
MORPHINE	10 MG/KG IM SC* Q2-4H	NARCOTIC II
PENTAZOCINE (TALWIN-V)	10 MG/KG SC IM IV	NON-NARCOTIC ANALGESIC IV
PENTOBARBITAL Na (NEMBUTAL)	36-90 MG/KG IP/***	BARBITUATE SHORT II
PHENCYCLADINE - DOSAGE	4 MG/KG IM	TRANQUILIZER
PHENCYCLADINE - DURATION	20-60 MIN	TRANQUILIZER
PHENCYCLADINE - TIME EFFECT	5-10 MIN	TRANQUILIZER
PHENCYLADINE - TIME FULL RECOVERY	2 HOURS	TRANQUILIZER
PHENYLBUTAZONE (BUTAZOLDIN)	100 MG/KG IP *7	NONSTEROIDAL ANTI-INFLAMMATORY
THIAMYLAL (SURITAL)	20-50 MG/KG IV IP	BARBITUATE ULTRASHORT III
THIOPENTAL (PENTOTHAL)	20 MG/KG IV****	BARBITUATE ULTRASHORT III
TILETAMINE/ZOLAZEPAM (TELAZOL) 50MG BASE/ML	20-80 MG/KG IP IM*	DISSOCIATE/TRANQUILIZER III
XYLAZINE (ROMPUN)- DOSAGE	4-8 MG/KG IM	ALPHA-2-ADRENERGIC AGONIST SEDATIVE, ANAGESIC, MUSCLE RELAXANT
ANESTHETIC GAS
HALOTHANE - MAC	0.95	INHALANT
ISOFLURANE - MAC		INHALANT
METHOXYFLURANE - MAC	0.22	INHALANT
NITROUS OXIDE-MAC	150	INHALANT
ANTI-INFLAMMATORY
DEXAMETHASONE (AZIUM)	0.06 MG SC IM IV IP	STEROID
PREDNISONE (METICORTIN)	0.05-0.22 MG SC IM	STEROID
ANTIBIOTIC
AMOXICILLIN	TOXIC**	ANTIBIOTIC
AMPICILLIN (POLYFLEX)	TOXIC**	BETA LACTAM ANTIBIOTIC
BACITRACIN	TOPICAL	ANTIBIOTIC
CEPHALORIDINE (LORIDINE)	? MG/KG IM Q24H (3 MG/120 GM) ***	BETA LACTAM ANTIBIOTIC
CHLORAMPHENICOL PALMITATE (CHLOROMYCETIN)	50 MG/KG PO TID (6 MG/120 GM)***	BACTERIAL STATIC BROAD SPEC.
CHLORAMPHENICOL SUCCINATE (CHLOROMYCETIN)	30 MG/KG IM Q12H // OR SC Q24H (3.6 MG/120 GM)*	BACTERIAL STATIC BROAD SPEC.
CLINDAMYCIN (CLEOCIN)	TOXIC**	BACTERIAL ORAL LESIONS
ERYTHROMYCIN	NEVER	BACTERIAL
GENTAMICIN (GENTOCIN)	5 MG/KG SC IM SID(0.6 MG/120 GM)***5D	AMINOGLYCOSIDES
GRISEOFULVIN (FULVICIN U/F)	25 MG/KG PO IN FOOD***	ANTIFUNGAL
LINCOMYCIN (LINCOCIN)	TOXIC**	BACTERIAL
NEOMYCIN (BIOSOL)	10 MG/KG PO Q24H // OR 100 MG/KG PO Q24H (12 MG/120 GM)//OR DW..44 MG/ML)**	DIARRHEA
NEOMYCIN SULFATE	2-10 GM/GAL H20 5D	AMINOGLYCOSIDES
OXYTETRACYCLINE (LIQUAMYCIN)	20 MG/KG SC SID (2.4 MG/120 GM)*//DW 0.25 MG/ML*	BACTERIAL STATIC BROAD SPEC.
PENICILLIN	NEVER	ANITBIOTIC
STREPTOMYCIN (BIOTEC)	NEVER	BACTERIAL
SULFAMETHAZINE OR SULFAMERAZINE	1 GM/L 5D (4ML-12.5%)	BACT. COCCIDIA,CIT,B
SULFAQUINOXALINE (SULQUIN)	DW 1 MG/KL ***	EIMERIA,KLOS. PAST.
TETRACYCLINES	TOXIC**	BACTERIAL STATIC BROAD SPEC//FROG RED LEG
TRIMETHOPRIM (40MG/ML)/SULPHADOXINE (200MG/ML) (TRIBRISSEN)	30MG/KG SC SID (3.6 MG/120 GM)***	TRIMETHOPRIM / SULPHONAMIDE
TYLOSIN	66 MG/L 21D/10 MG/KG // OR 10 MG/KG IM S C Q24H(1 MG/100 GM)***	MACROLIDES
ANTICHOLINERGIC
ATROPINE - DOSAGE	0.04 MG/KG SC IM// OR.1-3 MG/KG SC*	ANTICHOLINERGIC
ATROPINE - DURATION EFFECT	15 MIN	ANTICHOLINERGIC
ATROPINE - TIME TO EFFECT	10 MIN	ANTICHOLINERGIC
ANTIPARASITIC
CARBARYL POWDER (DIRYL)	5 D	ECTOPARASITIC
DICHLORVOS (TASK)	TOXIC	ECTOPARASITIC-SYPH, HETER
DICHLORVOS (VOPONA STRIPS)	STRIP 48H/WK	ECTOPARASITIC
IVERMECTIN (IVOMEC)	200MCG/KG PO SC***	ANTI-NEMATODES/ECTOPARASITIC
MEBENDAZOLE (TELMIN)	10 MG/KG PO 5D***	NEMATODIASIS COSMOCE
NICLOSAMIDE (YOMESAN)	100 MG/KG PO***	CESTODES-HYMENOLEPSIS
PIPERAZINE	100 MG/KG PO*** //3 MG/ML IN WATER + SYRUP *9	ANTI-NEMATODES-SYPHACIA & HET & PINWORMS
THIABENDAZOLE (TBZ; OMIZOLE)	100 MG/KG PO 5D***	ANTI-NEMATODES - OPHIDAS
HORMONE
OXYTOCIN	0.2-3 UNITS/KG SC IM *9	UTERINE/MILK HORM.

EUTHANASIA	Dose	Comments Back to Top
Sodium pentobarbital	150 mg/kg IP	Controlled substance
Halothane	To effect	High Concentration, Rapid flow
Isoflurane	To effect	High Concentration, Rapid flow
CO2	To effect	Requires some other method to ensure death
CO	To effect	See hazards under euthanasia training
Potassium chloride	1-2 mmol/kg IV IC	Requires general anesthesia
Cervical dislocation	Conditionally acceptable, Less than 200 grams	Requires scientific justification by user and approval of IACUC, Requires special training and monitoring
Decapitation	Conditionally acceptable	Requires scientific justification by user and approval of IACUC, Requires special training and monitoring, Hazard, requires special training for hazard, Equipment has to be maintained
Chloral hydrate	Unacceptable	Not used in Hamsters

Notes
= Anesthesia and Analgesia in Laboratory Animals: American College of Laboratory Animal Medicine: 1990 * = Laboratory Animal Anesthesia: Flecknell: 1989 * = Drug Dosages for Small Mammals: McKellar: 1989 *= Recognition and Alleviation of Pain and Distress in Laboratory Animals: NRC: 1992 5= Current Veterinary Therapy 2 Food Animal Practice 6 = University of Calif., San Fran., Morrish 7 = Basic Care of Experimental Animals 8= Therapeutic Guide and Anesthesia, O'Harndley 9= The Biology and Medicine of Rabbits and Rodents 10= ???????? Continuing Education Vol. 5, No. 4, April 1992 11 = USUHS Formulary 12 = LAB ANIMAL OCT 91 PAGE 34 13= ANESTHESIA AND ANALGESIC DOSES, SCHAEFFER, KNOXVILLE, TN