Amyloid-beta & Alzheimer's Disease
–McCardell Bicentennial Hall 104
276 Bicentennial Way
Middlebury, VT 05753 View in Campus Map
Open to the Public
Alzheimer’s Disease is characterized by large toxic fibrils and plaques in the brain. Amyloid-beta, a small, naturally occurring protein, is the major component of these fibrils and plaques. In order to understand the formation of the toxic forms of the protein, we would like to have a picture of Amyloid-beta in the free state, when not part of these fibrils or smaller aggregates. This is particularly difficult because unlike most proteins, which adopt a single, well-folded structure, Amyloid-beta is very flexible and constantly changes shape. However, we can use a combination of physics based computer simulations and biological NMR spectroscopy to understand Amyloid-beta structure and how this structure may influence toxicity and disease.
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