“LIPID RAFT DYSFUNCTION: A possible mechanism for neurodevelopmental disorders”.
The development of the brain is a highly complex and coordinated process, requiring biological signaling amongst diverse molecules. Lipid rafts are an important membrane microdomain that coordinates this signaling. We have shown that common developmental neurotoxicants (ex. ethanol, toluene, bilirubin) disrupt protein-lipid raft signaling. Further, we have shown that choline may ameliorate these effects.
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