“Visualizing the dynamic interactions between Plasmodium and mosquitos” - talk by Dr. Nathanie Trisnadi, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH. Malaria is a mosquito-borne disease responsible for over 200 million cases and 400,000 deaths each year. Efforts to reduce malaria transmission include blocking Plasmodium parasite development inside the mosquito vector. After a mosquito ingests infected blood, the parasite will invade the midgut which causes nitration reactions and irreversible damage in the mosquito. Invasion also stimulates hemocytes, cells part of the mosquito’s immune system. Parasites persist if they are able to migrate out the damaged cell and remain undetectable from hemocytes. We have developed live imaging methods to capture these processes. Our results show that immune responses are important to lower parasite survival within the mosquito. Sponsored by the Department of Biology.
Lunch available at 12:15pm. www.middlebury.edu/academics/bio
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