“The Role of B Cells in the Pathophysiology of Multiple Sclerosis”, Dr. Danielle E. Harlow, Teva Neuroscience

Science talk by Biology Class of 88 Speaker, Dr. Danielle E. Harlow, Medical Affairs, Teva Neuroscience, Formerly Research Instructor at University of Colorado Medical School.

My research has focused on aspects of the neuro-immune interactions underlying the autoimmune demyelinating disorder multiple sclerosis (MS). Depletion of B lymphocytes is an effective treatment for MS, suggesting a pathogenic role for B cells, although the underlying mechanisms of myelin damage remain unclear. Using an innovative ex vivo chimeric brain slice model, I¹ve investigated the interactions between B lymphocytes and cells of the central nervous system (CNS), particular astrocytes and oligodendrocytes. We have found a role for both pathogenic antibodies and cytokine production in B lymphocyte-induced myelin damage and have begun to elucidate the mechanisms by which myelin sheaths may be damaged in MS. (Lunch available at 12:15pm) Sponsored by The Biology Class of ’88 Lecture Fund, the Department of Biology, and Program in Molecular Biology and Biochemistry For details visit www.middlebury.edu/academics/bio/news