Presentation Title: Effect of NMDA receptor blockade, neurosteroid administration and operant response option on schizophrenia-like cognitive deficits.
Section: Advances in Health and Harm Reduction I
Location: McCardell Bicentennial Hall, 220
Date & Time: Friday, April 19, 2013 - 9:35am - 9:50am
Schizophrenia is a debilitating psychiatric disorder characterized in part by impaired cognition. One such deficit is cognitive flexibility, the ability to shift between rules or behavioral strategies as circumstances require. We investigated whether a GABA receptor positive modulator, the neurosteroid allopregnanolone, could alleviate cognitive flexibility deficits induced by the NMDA glutamate receptor antagonist MK-801. MK-801 administration induces cognitive deficits resembling those seen in schizophrenia. Male rats were trained on an operant task requiring them first to learn a discrimination rule based on either the presence of a lighted response key, or the location of a response key in the test chamber. Rats were then given injections of a control solution, MK-801, or allopregnanolone, alone or in combination, and trained on the alternative discrimination rule. Results suggest that MK-801 impaired cognitive flexibility relative to controls, and allopregnanolone, when co-administered with MK-801, alleviated cognitive deficits, but only in controlled-access response modules.Â Â Â
Type of Presentation: Individual oral
Presentation Area: Neuroscience
Number of presenters:
Presenter(s): Sackett, Deirdre
Class Year(s): 2013
Sponsor(s): Stefani, Mark R.
Dept(s): Dept. of Psychology, Program in Neuroscience