Presentation Title: Comparison of the Novel Object Recognition and Temporal Order Memory Tasks in a Rat Model of Schizophrenia
Section: Poster Session Group 2 2
Location: McCardell Bicentennial Hall, Great Hall
Date & Time: Friday, April 19, 2013 - 2:45pm - 3:30pm
Some of schizophreniaâ€™s most debilitating symptoms include impairments of working memory and recognition memory. Working memory is considered an â€œexecutive function,â€ and depends on functioning of the prefrontal cortex (PFC). Research suggests decreased inhibitory activity of the neurotransmitter GABA may underlie schizophreniaâ€™s cognitive symptoms. Restoration of GABA functioning in areas like the PFC thus has potential for schizophrenia treatment. Administration of the NMDA receptor antagonist MK-801 is a recognized preclinical schizophrenia model in rats, thought to work through GABA interference. This research examined how neural networks involved in two behavioral memory tasks â€“ novel object recognition (NOR) and the temporal order memory task (TMT) â€“ are altered by injection of MK-801, alone and combined with allopregnanolone directly into the PFC. Allopregnanolone is a positive GABAA receptor modulator. We hypothesized administration of MK-801 would impair working and recognition memory relative to control rats, and that allopregnanolone administration would block the MK-801-induced impairments.
Type of Presentation: Individual poster
Number of presenters:
Presenter(s): DiBiase, Florence Ann (Flo)
Class Year(s): 2013
Sponsor(s): Stefani, Mark R.