Middlebury

 

Presentation Title: Comparison of the Novel Object Recognition and Temporal Order Memory Tasks in a Rat Model of Schizophrenia

Section: Poster Session Group 2 2

Location: McCardell Bicentennial Hall, Great Hall

Date & Time: Friday, April 19, 2013 - 2:45pm - 3:30pm

Abstract:

Some of schizophrenia’s most debilitating symptoms include impairments of working memory and recognition memory. Working memory is considered an “executive function,” and depends on functioning of the prefrontal cortex (PFC). Research suggests decreased inhibitory activity of the neurotransmitter GABA may underlie schizophrenia’s cognitive symptoms. Restoration of GABA functioning in areas like the PFC thus has potential for schizophrenia treatment. Administration of the NMDA receptor antagonist MK-801 is a recognized preclinical schizophrenia model in rats, thought to work through GABA interference. This research examined how neural networks involved in two behavioral memory tasks – novel object recognition (NOR) and the temporal order memory task (TMT) – are altered by injection of MK-801, alone and combined with allopregnanolone directly into the PFC. Allopregnanolone is a positive GABAA receptor modulator. We hypothesized administration of MK-801 would impair working and recognition memory relative to control rats, and that allopregnanolone administration would block the MK-801-induced impairments.

Type of Presentation: Individual poster

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Presenter Information
Presenter(s): DiBiase, Florence Ann (Flo)
Major(s): Neuroscience
Class Year(s): 2013

Sponsor(s): Stefani, Mark R.
Dept(s): Psychology/Neuroscience

Moderator: ,