Middlebury

 

Presentation Title: The Effects of Bisphenol-A on Oocyte Maturation

Section: Disruption and its prevention II

Location: , 104

Date & Time: Friday, April 19, 2013 - 12:15pm - 12:30pm

Abstract:

Bisphenol-A is a chemical found in many plastics and consumer products. It is an endocrine disruptor with a similar structure to oestrogen. Studies have found that exposure to BPA results in increased incidence of meiotic arrest, alterations in spindle structure and perturbation in chromosome segregation. Studies have also found that exposure of ovarian fetal tissue to BPA causes oocyte degeneration, impairment of pairing synapsis and recombination and modifications to gene expression. In pursuing this project I hope to observe how BPA disrupts the oocyte, what concentrations of BPA affect the oocyte and further insight into the dangers of BPA to oocytes and fertility. 

More specifically, I will test for the first time low doses of BPA in the bovine model during the process of oocyte maturation.  The process of oocyte maturation occurs in vivo in the pre-ovulatory antral follicle, and low doses of BPA have been detected in the follicular microenvironment.  It is thus relevant to examine the specific effects of BPA on oocyte maturation, with the normal (or disrupted) progression of the process monitored with the evaluation of the cytoskeleton and chromosomes in each tested oocyte. 

Type of Presentation: Individual oral

Oral presenters
Presentation Area: Biology

Presentation Topic: Africa

Arts presenters
Format: 

Class Project
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Course Instructor: 
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Presenter Information
Presenter(s): Chateau, Gabriela (Gabby)
Major(s): Biology
Class Year(s): 2013

Sponsor(s): Combelles, Catherine M.
Dept(s): Biology

Moderator: ,