Presentation Title: The Effects of Prefrontal Inhibitory Signaling on Spatial Working Memory in a Rat Model for Schizophrenia
Section: Poster Session Group 2 2
Location: McCardell Bicentennial Hall, Great Hall
Date & Time: Friday, April 19, 2013 - 2:45pm - 3:30pm
Schizophrenia is a chronic and debilitating disorder that can greatly impair cognitive function, including working memory and cognitive flexibility. Recent research has linked these impairments to reduced inhibitory signaling by the neurotransmitter GABA within the prefrontal cortex. Our study tested the ability of a positive modulator of GABA activity, TCS-1205, to reverse working memory impairments induced by the NMDA receptor antagonist MK-801. MK-801 impairs cognition, in part by reducing GABA neuron activity, and is used as a model of schizophrenia. We injected MK-801 into the prefrontal cortices of adult male Sprague Dawley rats. Following drug injections, rats were tested for spontaneous alternation behavior, a measure of spatial working memory. We have seen a small decrease in spontaneous alternation performance in the treatment group given MK-801 when compared with the control group. Contrary to our working hypothesis, this decrease has been more pronounced in the groups given MK-801 and TCS-1205 simultaneously.
Type of Presentation: Individual poster
Number of presenters:
Presenter(s): Walker, Kara Siobhann
Class Year(s): 2013
Sponsor(s): Stefani, Mark R.