Presentation Title: Mesoderm and PGC specification in the axolotl embryo: The role of FGF in an alternate pathway
Section: Understanding the Past II
Location: McCardell Bicentennial Hall, 303
Date & Time: Friday, April 19, 2013 - 11:15am - 11:30am
Both the germ line and soma are specified together during the early stages of vertebrate mesoderm induction. Recent findings suggest a sequential gene regulatory network (GRN) in Ambystoma mexicanum, whereby Nodal induces Mix expression and Mix subsequently induces Brachyury expression. Xenopus laevis exhibits a more canalized pathway in which Mix and Brachyury are expressed independently. Independent Mix and Brachyury expression, as well as the five functionally redundant Nodal copies, allows for more rapid specification and is more evolutionarily robust. The linear nature of the axolotl pathway is, by comparison, inherently less robust. Despite this, the axolotl GRN mechanism represents the ancestral vertebrate state and, therefore, may not be as simple as the literature suggests. Mesoderm specification may alternatively act through FGF-8, which can be induced by exogenous FGF-10. This redundant mechanism has likely allowed it to become the ancestral vertebrate state and persist today.
Type of Presentation: Individual oral
Presentation Area: Biology
Number of presenters:
Presenter(s): Pepin, Tyler Michael
Class Year(s): 2013
Sponsor(s): Combelles, Catherine M.