Albert D. Mead Professor of BiologyInterests: Cancer biology, Neurobiology, Reproduction, STEM education
Biography and Research/Teaching Interests
As an undergraduate, I attended Cornell University and majored in cell biology and genetics. Following that, I attended the Weill Cornell Graduate School in Medical Sciences and received my Ph.D. in cancer biology from Memorial Sloan Kettering Institute where I studied the molecular cause of acute promyelocytic leukemia. I did my post-doctoral work at The Jackson Laboratory studying the genetic basis for accurate production of gametes during mammalian meiosis.
I am a broadly trained molecular geneticist and my laboratory group currently has four main research areas:
(1) The neurobiology of signal transduction in the brain
(2) Fundamental aspects of DNA recombination and genome integrity during
mitosis and meiosis
(3) The molecular genetics of fertility in mammals
(4) Science pedagogy
Our group's work has been funded by the National Institutes of Health, the National Science Foundation, and Middlebury College. We also have a an extensive network of lab alumni and collaborators and if you are interested in our work please don't hesitate to contact me.
Publications (bold type indicates Middlebury undergraduate co-authors)
Qiao, H., Prasada Rao, H. B. D., Yang, Y., Fong, J. H., Cloutier, J. M., Deacon, D. C., Nagel, K. E., Swartz R.K., Strong, E., Holloway, J.K., Cohen, P.E., Schimenti, J., Ward, J., and Hunter, N.(2014). Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet, 2014 Jan 5. doi:10.1038/ng.2858
Schimenti, K. J., Feuer, S. K., Griffin, L. B., Graham, N. R., Bovet, C. A., Hartford, S., Pendola, J., et al. (2013). AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics,194(2), 447-57. 2013 Jun. doi:10.1534/genetics.113.150789
Ward, J. O., Reinholdt, L. G., Motley, W. W., Niswander, L. M., Deacon, D. C., Griffin, L. B., Langlais, K. K., et al. (2007). Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet, 3(8), e139. 2007 Aug. doi:10.1371/journal.pgen.0030139
Kim, S., Namekawa, S. H., Niswander, L. M., Ward, J. O., Lee, J. T., Bardwell, V. J., & Zarkower, D. (2007). A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet, 3(4), e62. 2007 Apr 20. doi:10.1371/journal.pgen.0030062
Ward, J. O., Reinholdt, L. G., Hartford, S. A., Wilson, L. A., Munroe, R. J., Schimenti, K. J., Libby, B. J., et al. (2003). Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. Biol Reprod, 69(5), 1615-25. 2003 Nov. doi:10.1095/biolreprod.103.019877