Lesley-Ann Giddings

Asst. Professor of Chemistry/Biochemistry

 
 work(802) 443-5744
 On Leave 2018-2019
 McCardell Bicentennial Hall 447

Professor Lesley-Ann Giddings earned her B.A. in Chemistry at Smith College in Northampton, MA and Ph.D. in Biological Chemistry in the laboratory of Sarah O’Connor at the Massachusetts Institute of Technology in Cambridge, MA. After completing a 3-year postdoctoral fellowship with David Newman at the National Cancer Institute in Frederick, MD, she joined the chemistry & biochemistry faculty at Middlebury College in January of 2015. She currently teaches biochemistry, biochemistry lab, and metabolism.

Professor Giddings is a natural products chemist interested in exploiting and characterizing secondary metabolic biosynthetic pathways to identify new broad-spectrum antimicrobial agents as well as understand how Nature crafts novel pharmacophores. The Giddings lab approaches these problems by studying microbes (including extremophiles obtained from various EPA Superfund sites in Vermont) and using stressful growth conditions to induce cryptic gene clusters involved in secondary metabolism. The lab also uses basic biochemical techniques to characterize enzymes involved in secondary metabolic pathways found in microbes. Click here to learn more.

 

Select Publications

Lesley-Ann Giddings and David J. Newman. Bioactive Compounds from Extremophiles: Genomic Studies, Biosynthetic Gene Clusters, and New Dereplication Methods. Springer Briefs in Microbiology: Extremophilic Bacteria; Sonia M. Tiquia-Arashiro and Melanie Mormile, Eds. Springer: Cham, Germany, 2015.

Lesley-Ann Giddings and David J. Newman. Bioactive Compounds from Marine Extremophiles. Springer Briefs in Microbiology: Extremophilic Bacteria; Sonia M. Tiquia-Arashiro and Melanie Mormile, Eds. Springer: Cham, Germany, 2015.

Lesley-Ann Giddings and David J. Newman. Bioactive Compounds from Terrestrial Extremophiles. Springer briefs in Microbiology: Extremophilic Bacteria; Sonia M. Tiquia-Arashiro and Melanie Mormile, Eds. Springer: Cham, Germany, 2015.

Lesley-Ann Giddings and David J. Newman. Microbial Natural Products: Molecular Blueprints for Antitumor Drugs (2013). Journal of Microbiology and Biotechnology. 40, 1181 – 1210.

David J. Newman and Lesley-Ann Giddings. Natural Products as Leads to Antitumor Drugs (2013). Phytochemical Reviews.13,123 – 137.

Lesley-Ann Giddings*, David K. Liscombe*, and Sarah E. O'Connor. CYP71BJ1 Catalyzes a

Stereoselective Hydroxylation in Alkaloid Biosynthesis in Catharanthus roseus (2011). Journal of Biological Chemistry, 286, 16751 – 16757. (* these authors contributed equally)

Michael A. Hicks, Alan E. Barber II, Lesley-Ann Giddings, Jenna Caldwell, Sarah E. O’Connor, Patricia C. Babbitt. The Evolution of New Function in Strictosidine Synthase-Like Proteins (2011). Proteins: Structure, Function and Bioinformatics. 79, 3082 – 3098.

Justin Maresh, Lesley-Ann Giddings, Anne Friedrich, Elke A. Loris, Santosh Panjikar, Bernhardt L. Trout, Joachim Stöckigt, Baron Peters, and Sarah E O’Connor (2008). Strictosidine Synthase: Mechanism of a Pictet-Spengler Catalyzing Enzyme. Journal of the American Chemical Society. 130, 710 – 723.

Department of Chemistry & Biochemistry

McCardell Bicentennial Hall
276 Bicentennial Way
Middlebury College
Middlebury, VT 05753